Monkeypox symptoms typically begin with flu-like signs such as fever, chills, headache, muscle aches, and fatigue. These initial symptoms are followed by the appearance of a rash, which is a hallmark of the disease. The rash usually starts on the face and then spreads to other parts of the body, including the hands, feet, and genital area. The rash progresses through several stages, including flat red spots, raised bumps, and eventually, pustules that crust over.

Other symptoms may include swollen lymph nodes, which can be a distinguishing feature from similar illnesses like smallpox. Some people may experience back pain and respiratory symptoms such as cough or sore throat. In severe cases, complications can arise, such as secondary bacterial infections or issues with the eyes. It is essential to seek medical advice if these symptoms appear, especially if there has been exposure to a suspected case or contact with infected animals.